Schedule

We start with bioinformatics to learn fundamentals of genomics and transcriptomics. Afterwards, we will cover structure prediction, molecular simulations, and computer-aided drug design in our computational structural biology module.

Module 01 - Bioinformatics

Week 1

Thursday (Jan 9) Lecture 01A

• Topics: Computational biology overview.

Week 2

Tuesday (Jan 14) Lecture 02A

• Topics: DNA sequencing (Foundations)

Thursday (Jan 16) Lecture 02B

• Topics: DNA sequencing (Methodology)

Week 3

Tuesday (Jan 21) Lecture 03A

• Topics: Genome assembly (Foundations)

Thursday (Jan 23) Lecture 03B

• Topics: Genome assembly (Methodology)

Week 4

Tuesday (Jan 28) Lecture 04A

• Topics: Gene prediction (Foundations)
• Quiz 01

Thursday (Jan 30) Lecture 04B

• Topics: Gene prediction (Methodology)

Week 5

Tuesday (Feb 4) Lecture 05A

• Topics: Sequence alignment (Foundations)

Thursday (Feb 6) Lecture 05B

• Topics: Sequence alignment (Methodology)

Week 6

Tuesday (Feb 11) Lecture 06A

• Topics: Read mapping (Foundations)

Thursday (Feb 13) Lecture 06B

• Topics: Read mapping (Methodology)

Week 7

Tuesday (Feb 18) Lecture 07A

• Topics: Quantification (Foundations)
• Quiz 02

Thursday (Feb 20) Lecture 07B

• Topics: Quantification (Methodology)

Week 8

Tuesday (Feb 25) Lecture 08A

• Topics: Differential gene expression (Foundations)

Thursday (Feb 27) Lecture 08B

• Topics: Differential gene expression (Methodology)

Spring break

No class on Mar 4 and 6.

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Module 02 - Computational structural biology

Week 9

Tuesday (Mar 11) Lecture 09A

• Topics: Structural biology (Foundations)

Thursday (Mar 13) Lecture 09B

• Topics: Structural biology (Methodology)

Week 10

Tuesday (Mar 18) Lecture 10A

• Topics: Atomistic insight (Foundations)
• Quiz 03

Thursday (Mar 20) Lecture 10B

• Topics: Atomistic insight (Methodology)

Week 11

Tuesday (Mar 25) Lecture 11A

• Topics: Protein structure prediction (Foundations)

Thursday (Mar 27) Lecture 11B

• Topics: Protein structure prediction (Methodology)

Week 12

Tuesday (Apr 1) Lecture 12A

• Topics: Docking (Foundations)

Thursday (Apr 3): Lecture 12B

• Topics: Docking (Methodology)

Week 13

Tuesday (Apr 8) Lecture 13A

• Topics: Cheminformatics (Foundations)
• Quiz 04

Thursday (Apr 10) Lecture 13B

• Topics: Cheminformatics (Methodology)

Week 14

Tuesday (Apr 15) Lecture 14A

• Topics: Molecular simulations (Foundations)

Thursday (Apr 17) Lecture 14B

• Topics: Molecular simulations (Methodology)

Week 15

Tuesday (Apr 22) Lecture 14C

• Topics: Molecular simulations (Methodology)

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Final

Monday (Apr 28) Final exam from 4:00 - 5:50 pm.