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Lecture 09A
Structural biology

Foundations

Date: Mar 11, 2025

This foundational lecture introduces the field of structural biology, highlighting the biological significance of determining protein structure. Students will explore essential experimental techniques—X-ray crystallography and Cryo-EM—and understand their role, strengths, and limitations, including the challenges posed by structural disorder.

Learning objectives

After today, you should have a better understanding of:

  1. The definition and biological importance of structural biology.
  2. Basic principles of protein structure.
  3. X-ray crystallography and Cryo-electron microscopy.
  4. The challenge of protein disorder.

Supplementary material

Relevant content and readings for today's lecture.

Presentation